Competition driven by retinal waves promotes the 4 morphological and functional synaptic development of 5 neurons in the superior colliculus
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چکیده
Retinal waves promote synapse development 1 1 2 3
منابع مشابه
Competition driven by retinal waves promotes morphological and functional synaptic development of neurons in the superior colliculus.
Prior to eye opening, waves of spontaneous activity sweep across the developing retina. These "retinal waves," together with genetically encoded molecular mechanisms, mediate the formation of visual maps in the brain. However, the specific role of wave activity in synapse development in retino-recipient brain regions is unclear. Here we compare the functional development of synapses and the mor...
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Spontaneous retinal waves during development are thought to provide an instructive signal for precise retinotopic mapping by correlating the activity of neighboring retinal ganglion cells. In mutant mice (beta2-/-) that lack correlated waves, retinocollicular map refinement is impaired. In vivo recordings reveal that neurons in the superior colliculus of beta2-/- mice have large receptive field...
متن کاملSynapse maturation is enhanced in the binocular region of 4 the retinocollicular map prior to eye opening 5 6 Running head : Binocular map development prior to eye opening 7 8
19 20 In the developing visual system of mammals, retinal axons from the two eyes compete 21 for postsynaptic partners. After eye opening, this process is regulated in part by 22 homeostatically constrained competition for synaptic connectivity with target neurons. 23 However, prior to eye opening, the functional and synaptic basis of binocular map 24 development is unclear. To examine the role...
متن کاملSynapse maturation is enhanced in the binocular region of the retinocollicular map prior to eye opening.
In the developing visual system of mammals, retinal axons from the two eyes compete for postsynaptic partners. After eye opening, this process is regulated in part by homeostatically constrained competition for synaptic connectivity with target neurons. However, prior to eye opening, the functional and synaptic basis of binocular map development is unclear. To examine the role of binocular inte...
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NMDA receptors (NMDARs) play an important role in the structural maintenance and functional strength of synapses. The causal relationship between these anatomical and functional roles is poorly defined. Using quantitative confocal microscopy, synaptic vesicle immunoreactivity, and differential label of retinal projections, we measured axon volume and synapse density along ipsilateral retinal ax...
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تاریخ انتشار 2013